Although some instruments have been developed and validated to measure the quality of life in Colombian adolescents and adults, and there is a history of measuring this variable with children in the world, there is no evidence from similar studies in Colombia. For this reason, the objective of the following research was to develop construct validity and the reliability of the Spanish version of the Children Well-Being Scale [CPWS] in a population sample of 229 Colombian preschool children between 3 and 6 years of age. It is a cross-sectional study of descriptive scope and instrumental type, where the CPWS questionnaire was applied with parents of preschool children of both sexes living in the department of Córdoba, Colombia. Descriptive, dimensionality analysis of the models were developed through confirmatory factor analysis, Pearson correlation analysis, and a series of variance analysis (ANOVA) and t-tests of the CPWS factors according to the socio-demographic information of the participants.The results first indicated the confirmatory factor analyses performed support the factor structure of the CPWS proposed in the original validation in Iran. In addition, the psychometric indicators obtained in the Colombian translation correspond to the criteria of psychological well-being in children defined by the theory behind this type of instrument. Finally, the CPWS questionnaire as in the original questionnaire maintains 3 factors: self-concept, life satisfaction and resilience, with acceptable validity and reliability